Design and Interpretation of Clinical Trials
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Studying the phase 3 clinical trials, it is the most controlled phase out of the three. And it includes the basic comparison structure, parallel, crossover and group allocation design. Looking into parallel designs, there are factorial designs where different types of treatments are administered and large, simple designs where effect of treatment may not be seen in many people and data is easy to collect. Next up, testing for the hypothesis of the treatments other than proving its superiority would be testing for equivilance (similar effect as control) or non-inferiority (new treatment is as good as existing ones). Lastly, the adaptive design allows the trial to have the potential to improve its efficacy and not remain stagnant.