Design and Interpretation of Clinical Trials

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Brief description

Studying the phase 3 clinical trials, it is the most controlled phase out of the three. And it includes the basic comparison structure, parallel, crossover and group allocation design. Looking into parallel designs, there are factorial designs where different types of treatments are administered and large, simple designs where effect of treatment may not be seen in many people and data is easy to collect. Next up, testing for the hypothesis of the treatments other than proving its superiority would be testing for equivilance (similar effect as control) or non-inferiority (new treatment is as good as existing ones). Lastly, the adaptive design allows the trial to have the potential to improve its efficacy and not remain stagnant.

Lim Zhi Ying, Vernice




Overall, the course interest me as it allows me to further understand phase 3 of clinical trials, which is the last stage for a vaccine to be approved for commercial use. As of right now there are 11 Covid-19 vaccines in phase 3 and at any moment where one of them passes this phase, it can tremendously change the world for the better. The course is relevant to me as I intend to pursue a career related to research and it has definitely gave me an insight to the practical as well as admin side of research (publishing of clinical results etc.)